Special Warning to men: A study of  erectile drugs PDE-5 inhibitors in Queen's University Belfast, UK may harm male fertility - http://www.ncbi.nlm.nih.gov/pubmed/17335822?ordinalpos=1&
amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  due to the induced damage of acrosome that contains the chemicals which allow the sperm to break into an egg.

Advices:
0. Warning for pregnant women:  The dynamic orgasmic stretching of the uterus and cervix, in conjunction with the cortisol release from adrenal medulla and the oxytocin release from the pituitary gland where oxytocin is produced but preserved and stored under a high level of placenta progesterone during pregnancy, will induce excessive COX-2 mRNA expression for excessive prostaglandin E-2 release in the tissue; prostaglandin E-2 induces the labor and  softens/enlarges the cervical opening. Therefore, orgasm or mechanical stretching by the penile thrusting against the cervix and uterus can produce excessive Prostaglandin E-2 for the onset of labor!  Progesterone, with a lack of oxytocin can reduce COX-2 expression, while estrogen enhance it for swelling and fluid retention (or female ejaculation for some women).  The balance of progesterone and estrogen during pregnancy is very critical to secure the pregnancy during orgasm! A balancing increment of progesterone and estrogen in conjunction with androstenedione/testosterone and Nitric oxide will  boost prostaglandin E-1 production to allow the continuous uterine and low-abdomen expansion ( stretching the nerves without pains) for the fetal growth to the pregnancy term  until progesterone suddenly drops to induce excessive cortisol and then excessive prostaglandin E-2 release for induction of labor.   Please beware that Prostaglandin E-2 is responsible pre-term labor, miscarriage and cervix ripening, while prostaglandin E-2 initiates pregnancy: suppress the vaginal/cervic/uterine immune for sperm cells to survive, to fertilize the egg cells and then, to implant the fertilized egg into the uterine lining. In other words, Prostaglandin E-2 allow cells to be transplanted and to grow!
Generally speaking, excessive progesterone, without being balanced by estrogen and androstenedione/testosterone/DHT,  reduces the prostaglandins E-1 and E-3 synthesis for the vulva and vaginal abrasion pains and vaginal dryness during sex, particularly with a high level of sex-induced stress-hormone epinephrine cortisol release during sex arousal or after orgasm.  The excessive prostaglandin E-2 release induced by excessive vaginal/cervical abrasion and cervical/uterine contraction, in conjunction with (or as a result of ) excessive stress neurohormone epinephrine and another stressor cortisol release into in the bloodstream, can stimulate the progesterone release from the ovaries in an attempt to counterbalance the production of prostaglandin E-2. This will overload the ovarian function for the most of cases during non-pregnant condition. This is why excessive sex or orgasm can exhaust the ovarian function and will induce menstrual disorders for non-pregnant women.
1. A high level of Prostaglandin E-1 (PGE1),Prostaglandin E-2 (PGE2), 19-hydroxy-PGE1 and 19-hydroxy-PGE2 can cause premature labor for orgasmic, pregnant women.
2. Pain Killers COX-2 inhibitors can cause labor difficulty. Most of COX-2 inhibitors also inhibit COX-1. This will result in a deficiency of prostaglandin E-1 and E-3 in the cardiovascular tissue, brain, stomach lining, prostate, penis, uterus, vagina, joints and all the other tissues.  Both prostaglandin E-1 and E-3 supports your cardiovascular health, orgasm  and of course healing and restoration. 
3. Prostaglandin E-2 is an immune suppressor that suppresses the vaginal antibiotic nature for sperms to survive in the vagina. It also stimulates the cervical tissue to open the cervical orifice for sperms to swimming into the uterus. However, if your vagina is severely abraded by intercourse, you will get Vaginosis / Yeast Infection & Orgasm
or Vulvodynia (vulva abrasion) due to prostaglandin E-2's immune suppression. 

On Taoist's ejaculation frequency vs testosterone level and sperm concentration.; 5000-years Sexual exhaustion symptoms were also mentioned by the Seventh-day Adventist church; what is a consistence of old culture wisdoms!
==> http://www.actionlove.com/cases/case15675.htm

Ejaculatory Frequency and Season Change vs Semen Quality: according to http://www.ncbi.nlm.nih.gov/pubmed/15302284?dopt=Abstract , Increasing your ejaculatory frequency will drop your sperm concentration, but there is no seasonal variations in sperm concentration, motility, or morphology. Compared with one ejaculation per week, sperm concentration fell 29% with two ejaculations per week, and by 41% with three ejaculations per week.  Noticeable, the spring ejaculatory frequency is significantly higher in spring months than the winter's.  Note:  the pituitary-testicular axis and the skin endocrine function respond to the seasonal temperature change, and more active in warm weather.

Ejaculation Frequency vs. Testosterone Level: 
1. http://www.ncbi.nlm.nih.gov/pubmed/12659241?dopt=Abstract - "The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change."  also in http://www.ncbi.nlm.nih.gov/pubmed/12506329?ordinalpos=2&itool=EntrezSystem2.PEntrez
.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
2. http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract - "This current study examined the effect of a 3-week period of sexual abstinence on the neuroendocrine response to masturbation-induced orgasm. Hormonal and cardiovascular parameters were examined in ten healthy adult men during sexual arousal and masturbation-induced orgasm. Blood was drawn continuously and cardiovascular parameters were constantly monitored. This procedure was conducted for each participant twice, both before and after a 3-week period of sexual abstinence. Plasma was subsequently analysed for concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone and testosterone concentrations. Orgasm increased blood pressure, heart rate, plasma catecholamines and prolactin. These effects were observed both before and after sexual abstinence. In contrast, although plasma testosterone was unaltered by orgasm, higher testosterone concentrations were observed following the period of abstinence. These data demonstrate that acute abstinence does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males."
3. American population testosterone level dropped about 50 ng/dl for men at around age 64-65 between 2 groups of men born in 1920-1924 and 1930-1934, according to in http://jcem.endojournals.org/cgi/reprint/92/1/196. When the 1920-1924 group reached the median age 65, their mean testosterone level was 500 ng/dl; when the 1930-1934 group reached the median age 56 and 64, their mean testosterone was 529 ng/dl and 444 ng/dl, respectively. The 1930-1934 group has a testosterone drop rate at about 10.65 ng/dl per year during ages 56-64. This report also shows that the testosterone drop rate generally becomes faster for the men from 55 to 65. If we use the same annual drop rate of the 1930-1934 group, the extrapolated, averaged testosterone level of of 20 year old men born during 1930-1934 should be about 911 ng/dl.  Assuming that the mean 20-year old testosterone level for both groups are the same  is about  911 ng/dl, the overall-averaged testosterone drop for the 1920-1924 group is about 9.13 ng/dl/year, while the overall- averaged testosterone drop for the 1930-1934 group  is about 10.61 ng/dl/year  I suspect the higher masturbation/ejaculation frequency in the younger generation after the 60's sexual revolution resulted in a higher cortisol/ prolactin level (or faster ageing of the hypothalamus-pituitary-adrenal and -testicular axis) accelerates the testosterone drop, since some high-frequency over-masturbation young men experience male menopause (andropause) between ages 20-30. 
Empirical Examples of Re-activation of Reproduction Stem Cells
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Warning: Dog sex induced powerful sexual orgasm, with excessive prostaglandin E-2 in semen,  resulted in miscarriage - side effect of powerful sexual orgasm with excessive inflammatory and labor-inducer prostaglandin E-2
==> http://www.actionlove.com/cases/case13821.htm
Warning: semen's prostaglandin E-2 (from animals or human) and intercourse can promote uterine and cervix prostaglandin E-2 release for cervix and uterine contraction to miscarriage with too much sexual orgasm. How to reduce uterine prostaglandin E-2 release to secure pregnancy.
==> http://www.actionlove.com/cases/case14126.htm
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Causes and solution for postpartum depression and syndromes - restoration of libido and more sexual orgasm
==> http://www.actionlove.com/cases/case15556.htm
Polycystic ovary syndrome (PCOS), infertility and its associated irregular period - possible cause and solution.
==> http://www.actionlove.com/cases/case16352.htm
Chronic use of Non-steroidal anti-inflammatory drug (NSAID) killed her ovarian function and prostaglandins production for no more Sex and, of course, no more sexual orgasm. Warning: NSAID drugs can kill the ovarian and testicular function via inhibition of prostaglandin E-1, E-2 and E-3, and can cause pregnancy, labor and childbirth difficulty!
==> http://www.actionlove.com/cases/case14114.htm
20-year over-masturbation at 3-4 times a day results in eye floater, body pain, buzzing ears, frequent urination, premature ejaculation and infertility for no more sexual orgasm
http://www.actionlove.com/cases/case15866.htm
Chronic pot (marijuana) smoking, hashish abuse, and over-masturbation resulted in infertility (zero sperm counts) for no more sexual orgasm
http://www.actionlove.com/cases/case15280.htm
Birth control shot for pseudo menopause can result in infertility and no more sexual orgasm.
==> http://www.actionlove.com/cases/case13623.htm 

Pot / marijuana chemicals can reduce the semen and sperm production and alternate the semen quality and quantity essential to sperm survival.
==> http://www.actionlove.com/cases/case16789.htm
Chronic over-masturbation at 3-6 times a day results in eye floaters, cloudy vision, eye spider webs, ear ringing, sleeping disorders (insomnia) and infertility.
==> http://www.actionlove.com/cases/case15783.htm
Elevation of prolactin causes ovarian disorders for excessive vaginal discharge and yeast infection for no sexual orgasm and postpartum depression. Breastfeeding, excessive sex or drug drugs can be the causes.
http://www.actionlove.com/cases/case14827.htm
Pregnant women should avoid powerful sexual orgasm, particularly induced by a deep penetration and a high level of prostaglandin E-2 such as dog sex and semen.
http://www.actionlove.com/cases/case14744.htm
Why drug abuse and antidepression drugs result in excessive prostaglandin E-2 and epinephrine release to induce psychological disorders ( mood swing, anger, and aggression), extremely headaches, shooting pains low stomach swelling, body pains, body heat, light headedness confusion, uncontrollable over-masturbation (persistent sexual arousal), particularly during ovulation, for no more sexual orgasm
==>http://www.actionlove.com/cases/case14644.htm
Chronic over-masturbation damaged his testicles for no sperm production and no more sexual orgasm.
==> http://www.actionlove.com/cases/case14604.htm
Pot chemicals damaged his hypothalamus-pituitary-testicular function for low libido, erectile dysfunction,  sperm production disorder and no more sexual orgasm.
==> http://www.actionlove.com/cases/case14555.htm
Chronic Over-masturbating 3-4 times a day (persistent sexual arousal symptoms) resulted in excessive prostaglandin E-2 and prolactin release for frequent vaginal discharge, abdomen pains for no more sexual orgasm. Prostaglandin E-2 suppresses the immune to initiate life, but excessive prostaglandin E-2 without sufficient prostaglandin E-1 to counterbalance it gives you painful and weak-immune life after you were born.
http://www.actionlove.com/cases/case14459.htm
Excessive sex and vibrator use resulted in Parkinson-disease-like leg shaking during sex, feet inflammation and infertility for no more sexual orgasm.
==> http://www.actionlove.com/cases/case14415.htm
Anti-depression/anti-anxiety and erectile drugs killed his brain, penis, testicles and sperm/semen production for lightheadedness, headaches, and stomachaches, infertility and no sexual orgasm
==> http://www.actionlove.com/cases/case14372.htm
Postpartdum Disorder for no libido and no sexual orgasm
==> http://www.actionlove.com/cases/case14269.htm
Excessive prostaglandin E-2 production in the uterus and cervix can cause miscarriage, excessive vaginal discharge, and female ejaculation  for no more sexual orgasm - the natural solution with foods for reduction of miscarriage
http://www.actionlove.com/cases/case14339.htm
Chronically over-ejaculating/over-masturbating 2-3 times a day resulted in infertility for no more sexual orgasm
http://www.actionlove.com/cases/case13756.htm
Severe precum and semen leakage affected the semen quality for infertility and no more sexual orgasm!
==> http://www.actionlove.com/cases/case13252.htm
Chronic use of hormone-based birth control can result in the birth-control withdrawal symptoms - premature peri-menopause symptoms or even menopause symptoms for no more babymaking and sexual orgasm !
==> http://www.actionlove.com/cases/case13237.htm
Nipple suction induces sexual orgasm and milk release;  breastfeeding can shrink the uterus back to the normal size faster after childbirth!
http://www.actionlove.com/cases/case13189.htm
The birth control shot can result in menopause for no more sexual orgasm and baby making.
http://www.actionlove.com/cases/case13172.htm
Pregnancy and sexual orgasm
http://www.actionlove.com/cases/case12965.htm
Chronic over-masturbation has shut down his semen and sperm production for male infertility and no more sexual orgasm
http://www.actionlove.com/cases/case12960.htm
Can dog semen induces miscarriage? A warning for sexual orgasm!
==> http://www.actionlove.com/cases/case12786.htm
over-masturbation or/and excessive sexual orgasm since age 8 or 9 causes this 32-year old woman's uncontrollable bleeding, irregular menstruation, and infertility.
==> http://www.actionlove.com/cases/case12463.htm
Chronic Over-masturbation causes a chronic elevation of prolactin for seminal / sperm production disorder, low libido, orgasmic disorder for infertility and no more sexual orgasm!
http://www.actionlove.com/cases/case12388.htm
Postpartdum Disorder for no libido, no sexual orgasm and possible weight gain and depression - why and solution
==>http://www.actionlove.com/cases/case12252.htm
How to increase the pregnancy chance for women with irregular period, and sexual orgasm too!
==>http://www.actionlove.com/cases/case11952.htm
Why excessive sexual orgasms, including sleeping orgasms, can destroy pregnancy and cause miscarriage or premature childbirth - the problem of very orgasmic women.
==>http://www.actionlove.com/cases/case12001.htm
Birth control pills emulate a pregnant condition and let her experience pregnant symptoms for no more sexual orgasm
==> http://www.actionlove.com/cases/case12189.htm